Melanocortin receptor 4 (MC4R) is a 332-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P32245.
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The mean pLDDT of this model is 80.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 49% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha- and beta-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor (PubMed:12646665, PubMed:14764818, PubMed:25163632, PubMed:32327598, PubMed:33858992, PubMed:8392067). Functions as a central component of the leptin-melanocortin pathway, which is essential for maintaining energy homeostasis (PubMed:32327598, PubMed:33858992). Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway, which promotes anorexogenic signaling in the hypothalamus and contributes to a negative energy balance (PubMed:12588803, PubMed:14764818, PubMed:25163632,…
Homodimer; disulfide-linked, also forms higher order oligomers. Interacts with GNAS (PubMed:33858992). Interacts with ATRNL1 (By similarity). Interacts with MGRN1; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. Interacts with MRAP and MRAP2; these associated factors increase ligand-sensitivity and generation of cAMP. Forms a complex with OPN3 and…
Cell membrane, Cell projection, cilium membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7PIU | EM | 2.58 Å | R=1-332 |
| 6W25 | X-ray | 2.75 Å | A=16-222, A=236-320 |
| 7PIV | EM | 2.86 Å | R=1-332 |
| 8WKY | X-ray | 2.9 Å | A=16-222, A=236-320 |
| 7AUE | EM | 2.97 Å | R=1-332 |
| 7F53 | EM | 3.0 Å | R=1-332 |
| 7F54 | EM | 3.0 Å | R=1-332 |
| 7F55 | EM | 3.1 Å | R=1-332 |
| 7F58 | EM | 3.1 Å | R=1-332 |
| 9K3K | EM | 3.12 Å | R=1-332 |
| 8WKZ | X-ray | 3.3 Å | A=16-222, A=236-320 |
| 8QJ2 | EM | 3.4 Å | A=1-332 |
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