Cell cycle serine/threonine-protein kinase CDC5/MSD2 (CDC5) is a 705-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P32562.
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The mean pLDDT of this model is 79.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 48% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Protein kinase required for the cell cycle where it is involved in mitotic exit (PubMed:11371343, PubMed:32099015). A component of the fear (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase (PubMed:11832211, PubMed:32099015). Phosphorylates SCC1/MCD1 and NET1 (PubMed:12056824)
Interacts with CDC48; the interaction is likely to result in CDC5 degradation (PubMed:14636562). Interacts with CSA1 (PubMed:32553169)
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6MF4 | X-ray | 1.8 Å | A=418-705 |
| 6MF5 | X-ray | 2.7 Å | A/B=418-705 |
| 6MF6 | X-ray | 3.4 Å | A/B=418-705 |
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