Checkpoint protein RAD24 (RAD24) is a 659-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P32641.
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The mean pLDDT of this model is 74.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 31% |
| 70 to 90 | Confident: backbone generally right | 37% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 22% |
What pLDDT means and how to read it
Participates in checkpoint pathways arrest of the cell cycle, a mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. Regulates the DNA damage checkpoint pathway throughout the cell cycle, when associated with RCF5. Component of the RFC-like RAD24-RFC complex which loads the checkpoint clamp DDC1:MEC3:RAD17 complex and is involved in DNA repair pathways. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one…
Component of the RAD24-RFC complex which consists of RAD14, RFC2, RFC3, RFC4 and RFC5 and associates with the checkpoint clamp DDC1:MEC3:RAD17 complex. RAD24 interacts with ECO1
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8DQW | EM | 2.1 Å | A=1-659 |
| 7ST9 | EM | 2.2 Å | A=1-659 |
| 7STB | EM | 2.72 Å | A=1-659 |
| 7STE | EM | 2.73 Å | A=1-659 |
| 8FS5 | EM | 2.76 Å | A=1-545 |
| 8FS7 | EM | 2.85 Å | A=1-545 |
| 8FS6 | EM | 2.9 Å | A=1-545 |
| 8FS3 | EM | 2.93 Å | A=1-545 |
| 8FS4 | EM | 2.94 Å | A=1-544 |
| 8FS8 | EM | 3.04 Å | A=1-499 |
| 7SGZ | EM | 3.17 Å | A=1-659 |
| 7SH2 | EM | 3.23 Å | A=1-659 |
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