Protein transport protein SEC61 (SEC61) is a 480-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P32915.
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The mean pLDDT of this model is 70.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 57% |
| 50 to 70 | Low: treat with caution | 39% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Part of the Sec61 complex, which is the major component of a channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). The functional states of the translocon complex include co- and post-translational ER import, cotranslational membrane protein integration and retrograde transport of misfolded proteins out of the ER. In the cotranslational pathway, ribosomes synthesizing presecretory proteins are targeted to the translocon by the cytosolic signal recognition particle (SRP) and its ER-localized receptor. The association of the Sec61 complex with the ribosome is mediated by the 28S rRNA of the large ribosomal subunit. SRP-independent…
Component of the heterotrimeric Sec61 complex, which is composed of SEC61, SBH1 and SSS1. Presumably three to four Sec61 heterotrimers assemble into an oligomeric ring with a central aqueous pore. In cotranslational ER import, the pore diameter varies from 9-15 A in a ribosome-free resting state to 40-60 A in a functional state when associated with the ribosome. The Sec61 complex is part of a…
Endoplasmic reticulum membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7KAH | EM | 3.1 Å | A=1-480 |
| 7KAJ | EM | 3.1 Å | A=1-480 |
| 7KAI | EM | 3.2 Å | A=1-480 |
| 6N3Q | EM | 3.68 Å | A=1-480 |
| 7KB5 | EM | 3.8 Å | A=1-480 |
| 7KAS | EM | 3.9 Å | A=1-480 |
| 7KAO | EM | 4.0 Å | A=1-480 |
| 7KAQ | EM | 4.0 Å | A=1-480 |
| 7KAR | EM | 4.0 Å | A=1-480 |
| 7KAU | EM | 4.0 Å | A=1-480 |
| 6ND1 | EM | 4.1 Å | B=1-480 |
| 7KAP | EM | 4.1 Å | A=1-480 |
| 7AFT | EM | 4.4 Å | A=1-480 |
| 7KAT | EM | 4.4 Å | A=1-480 |
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