Histone acetyltransferase SAS3 (SAS3) is a 831-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P34218.
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The mean pLDDT of this model is 57.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 19% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 51% |
What pLDDT means and how to read it
Catalytic component of the NuA3 histone acetyltransferase complex, that acetylates H3K14 (PubMed:10600516, PubMed:10817755, PubMed:11731478, PubMed:16581777, PubMed:17157260, PubMed:25104842). The NuA3 HAT complex has 2 functionally distinct forms. NuA3a binds H3K4me3, through the PHD finger of YNG1, and acetylates H3K14 at the promoter region of actively transcribed genes to promote transcription initiation. NuA3b binds H3K36me3 at the coding regions of actively transcribed genes, through the PWWP domain of PDP3, and coordinates transcription elongation (PubMed:17157260, PubMed:25104842). In vitro, SAS3 acetylates free histones H3 and H4 (PubMed:10600516). It is involved in silencing the…
Component of the NuA3 histone acetyltransferase (HAT) complex (PubMed:17157260). The NuA3 HAT complex has 2 functionally distinct forms that participate in transcription (PubMed:25104842). The NuA3a HAT complex is composed of at least NTO1, SAS3, TAF14, YNG1 and EAF6 (PubMed:17157260). The NuA3b HAT complex contains an additional subunit, PDP3 (PubMed:25104842). SAS3 interacts with CDC68/SPT16…
Nucleus
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