Corticotropin-releasing factor receptor 1 (CRHR1) is a 415-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P34998.
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The mean pLDDT of this model is 77.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 23% |
| 70 to 90 | Confident: backbone generally right | 48% |
| 50 to 70 | Low: treat with caution | 20% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
G protein-coupled receptor for CRH and UCN stress hormones, which plays a central role in whole body adaptation to stress (PubMed:18292205, PubMed:18801728, PubMed:20966082, PubMed:23576434, PubMed:23863939, PubMed:24290358, PubMed:32004469, PubMed:32004470). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and downstream effectors, such as adenylate cyclase (PubMed:18292205, PubMed:32004469, PubMed:32004470). CRHR1 is mainly coupled to G(s) G protein (GNAS), mediating activation of adenylate cyclase activity and production of cAMP (PubMed:18292205, PubMed:32004469, PubMed:32004470). In some conditions, can also couple…
Heterodimer; heterodimerizes with GPER1 (By similarity). Interacts with DLG1; this inhibits endocytosis of CRHR1 after agonist binding (PubMed:23576434)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3EHU | X-ray | 1.96 Å | A/B=24-119 |
| 8GTI | X-ray | 2.2 Å | A=104-373 |
| 8GTM | X-ray | 2.6 Å | A=104-373 |
| 8GTG | X-ray | 2.75 Å | A=104-373 |
| 3EHS | X-ray | 2.76 Å | A=24-119 |
| 6P9X | EM | 2.91 Å | R=23-415 |
| 4K5Y | X-ray | 2.98 Å | A/B/C=104-344 |
| 6PB0 | EM | 3.0 Å | R=24-398 |
| 4Z9G | X-ray | 3.18 Å | A/B/C=104-220, A/B/C=223-372 |
| 3EHT | X-ray | 3.4 Å | A=24-119 |
| 2L27 | NMR | A=25-108 |
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