Prostaglandin G/H synthase 2 (PTGS2) is a 604-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P35354.
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The mean pLDDT of this model is 93.0 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 91% |
| 70 to 90 | Confident: backbone generally right | 1% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response (PubMed:11939906, PubMed:16373578, PubMed:17519235, PubMed:19540099, PubMed:22942274, PubMed:26859324, PubMed:27226593, PubMed:7592599, PubMed:7947975, PubMed:9261177). The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes (PubMed:16373578,…
Homodimer
Microsome membrane, Endoplasmic reticulum membrane, Nucleus inner membrane, Nucleus outer membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5F19 | X-ray | 2.04 Å | A/B=19-569 |
| 5IKR | X-ray | 2.34 Å | A/B=19-569 |
| 5F1A | X-ray | 2.38 Å | A/B=19-570 |
| 5IKQ | X-ray | 2.41 Å | A/B=19-569 |
| 5IKT | X-ray | 2.45 Å | A/B=19-569 |
| 5IKV | X-ray | 2.51 Å | A/B=19-569 |
| 5KIR | X-ray | 2.7 Å | A/B=19-569 |
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