Endonuclease CUE2 (CUE2) is a 443-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P36075.
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The mean pLDDT of this model is 68.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 12% |
| 70 to 90 | Confident: backbone generally right | 50% |
| 50 to 70 | Low: treat with caution | 16% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
mRNA endonuclease involved in the No-Go Decay (NGD) pathway, which catalyzes mRNA cleavage and degradation in response to ribosome collisions (PubMed:31219035, PubMed:36583309). Acts downstream of the ribosome collision sensor HEL2 (PubMed:36583309). Specifically recognizes and binds RPS7/eS7 polyubiquitinated by MOT2/NOT4 and HEL2, promoting CUE2 recruitment to stalled ribosomes, where it mediates mRNA cleavage upstream of the colliding ribosome (PubMed:36583309). Also mediates mRNA cleavage within colliding ribosomes: recruited to colliding ribosomes downstream of the RQT (ribosome quality control trigger) complex following disassembly of stalled ribosomes and cleaves mRNAs partially…
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1OTR | NMR | A=6-54 |
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