Drosocin antimicrobial peptides (Dro) is a 64-residue protein from Drosophila melanogaster. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P36193.
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The mean pLDDT of this model is 73.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 9% |
| 70 to 90 | Confident: backbone generally right | 48% |
| 50 to 70 | Low: treat with caution | 42% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Antibacterial peptide with strong anti-Gram-negative bacteria activity (PubMed:8325867). Significantly contributes to antibacterial activity against Enterobacter cloacae but not Providencia burhodogranariea (PubMed:35730150). Inhibitor of bacterial translation machinery that targets translation termination in a prfA- or prfB-dependent manner (PubMed:36997646). Binds within the nascent peptide exit tunnel of the bacterial large ribosomal subunit, potentially interfering with nascent chain translocation that occurs post-peptide bond formation (PubMed:36997646, PubMed:36997647). Binds prfA/RF1 (and potentially prfB/RF2), trapping it on the ribosome after release of the nascent polypeptide…
Associates with the bacterial 50S ribosomal complex, occupying the nascent peptide exit tunnel (PubMed:36997646). Interacts with bacterial 23S rRNA; this interaction is direct (PubMed:36997646, PubMed:36997647). Interacts with bacterial rplV/50S ribosomal protein L22; this interaction is direct (PubMed:36997646, PubMed:36997647). Interacts with bacterial prfA/peptide chain release factor RF1;…
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4EZR | X-ray | 1.9 Å | B=33-40 |
| 8ANA | EM | 2.0 Å | A=22-40 |
| 6Z2P | X-ray | 2.16 Å | C=22-40 |
| 8AKN | EM | 2.3 Å | A=22-40 |
| 6Z2Q | X-ray | 2.35 Å | D=22-40 |
| 8AM9 | EM | 2.8 Å | A=22-40 |
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