Complement factor H-related protein 2 (CFHR2) is a 270-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P36980.
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The mean pLDDT of this model is 90.6 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 80% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism
Head-to-tail homodimer and heterodimer with CFHR1 or CFHR5
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3ZD1 | X-ray | 2.0 Å | A/B=147-270 |
| 5EA0 | X-ray | 2.0 Å | P=150-162 |
| 9N1Z | X-ray | 2.31 Å | B/D=145-270 |
| 9N20 | X-ray | 3.3 Å | B=145-270 |
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