Omega-conotoxin MVIIC is a 29-residue protein from Conus magus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P37300.
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The mean pLDDT of this model is 85.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 24% |
| 70 to 90 | Confident: backbone generally right | 72% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin preferentially blocks P/Q-type calcium channels (Cav2.1/CACNA1A) (IC(50)=0.60 nM) (PubMed:10938268, PubMed:1352986). Also shows an inhibition on Cav2.2/CACNA1A channels (IC(50)=7.0 nM) (PubMed:10938268)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
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