Vitamin K-dependent gamma-carboxylase (GGCX) is a 758-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P38435.
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The mean pLDDT of this model is 86.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 64% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant epoxidation of vitamin K hydroquinone to vitamin K epoxide (PubMed:17073445, PubMed:39880952, PubMed:39880037). Couples epoxidation and carboxylation in the same active site (PubMed:39880952, PubMed:39880037). Catalyzes gamma-carboxylation of blood coagulation factors (F2, F7, F9 and F10) and anticoagulants such as PROC, which are essential for thrombosis(PubMed:17073445, PubMed:39880037). Catalyzes gamma-carboxylation of osteocalcin/BGLAP, which is essential for bone metabolism (PubMed:17073445, PubMed:39880952). Catalyzes gamma-carboxylation…
Monomer (PubMed:11570873, PubMed:39880952, PubMed:39880037). May interact with CALU (By similarity)
Endoplasmic reticulum membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9L25 | EM | 2.41 Å | A=32-729 |
| 9L6S | EM | 2.58 Å | A=1-758 |
| 9L6R | EM | 2.59 Å | A=1-758 |
| 9L21 | EM | 2.62 Å | A=32-729 |
| 9L23 | EM | 2.62 Å | A=32-729 |
| 9WF3 | EM | 2.65 Å | A=32-728 |
| 9L6Q | EM | 2.78 Å | A=1-758 |
| 9L20 | EM | 2.82 Å | A=32-729 |
| 9WF9 | EM | 2.83 Å | A=32-728 |
| 9WF2 | EM | 2.94 Å | A=32-728 |
| 9WFN | EM | 2.94 Å | A=32-727 |
| 9BUR | EM | 2.95 Å | A=1-758 |
| 9L54 | EM | 3.04 Å | A=32-729 |
| 9BUX | EM | 3.06 Å | A=1-758 |
| 9L24 | EM | 3.1 Å | A=32-729 |
| 9MQC | EM | 3.13 Å | A=1-758 |
| 9BVP | EM | 3.3 Å | A=26-758 |
| 9BVQ | EM | 3.3 Å | A=27-758 |
| 9WFC | EM | 3.33 Å | A=32-728 |
| 9MQB | EM | 3.37 Å | A=1-758 |
Showing 20 of 28 experimental structures (best resolution first).
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