Class E vacuolar protein-sorting machinery protein HSE1 (HSE1) is a 452-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P38753.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 74.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 26% |
| 70 to 90 | Confident: backbone generally right | 45% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 22% |
What pLDDT means and how to read it
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane
Component of the ESCRT-0 complex composed of HSE1 and VPS27 (PubMed:12055639). Interacts with the ESCRT-I subunit VPS23, the UBP7 deubiquitinase and the E3 ligase RSP5 (PubMed:15086794, PubMed:17079730). May form a complex composed of VPS27, HSE1 and DOA1 (PubMed:18508771). Interacts (via SH3 domain) with DOA1 (PubMed:18508771)
Endosome membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2PJW | X-ray | 3.01 Å | H=288-375 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.