Kinetochore protein NDC80 (NDC80) is a 691-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P40460.
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The mean pLDDT of this model is 77.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 37% |
| 70 to 90 | Confident: backbone generally right | 35% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Acts as a component of the essential kinetochore-associated NDC80 complex, which is involved in chromosome segregation and spindle checkpoint activity
Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25. The NDC80 complex is formed by two subcomplexes, NDC80-NUF2 and SPC24-SPC25, which are joined end-to-end through their coiled-coil domains. It has a rod-like structure with a length of 570 Angstroms and globular domains at either end. The NDC80-NUF2 globular domains are probably directed to microtubules, the…
Nucleus, Chromosome, centromere, kinetochore
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7KDF | X-ray | 2.72 Å | A=114-689 |
| 5TCS | X-ray | 2.83 Å | A=114-689 |
| 8V10 | X-ray | 3.02 Å | A=114-691 |
| 8Q84 | EM | 3.15 Å | A/F=1-691 |
| 8G0Q | X-ray | 3.22 Å | A/C=106-691 |
| 8QAU | EM | 3.54 Å | A=1-691 |
| 8V11 | X-ray | 3.95 Å | A/E=114-684 |
| 8Q85 | EM | 3.97 Å | F=1-691 |
| 5TD8 | X-ray | 7.53 Å | A=114-691 |
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