25S rRNA (cytosine(2870)-C(5))-methyltransferase (NOP2) is a 618-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P40991.
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The mean pLDDT of this model is 73.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 24% |
| 70 to 90 | Confident: backbone generally right | 44% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA. Required for 60S ribosomal subunit synthesis and processing
Interacts with NOP53. Interacts with TRM112
Nucleus, nucleolus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8V83 | EM | 2.53 Å | q=1-618 |
| 8V87 | EM | 2.66 Å | q=1-618 |
| 8V84 | EM | 2.7 Å | q=1-618 |
| 7NAC | EM | 3.04 Å | q=1-618 |
| 7R7A | EM | 3.04 Å | q=1-618 |
| 7NAF | EM | 3.13 Å | q=285-320 |
| 7R6K | EM | 3.17 Å | q=1-618 |
| 6ELZ | EM | 3.3 Å | q=1-618 |
| 7R7C | EM | 3.71 Å | q=1-618 |
| 6EM5 | EM | 4.3 Å | q=1-618 |
| 7OHR | EM | 4.72 Å | q=1-618 |
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