Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (OST1) is a 476-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P41543.
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The mean pLDDT of this model is 86.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 61% |
| 70 to 90 | Confident: backbone generally right | 29% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity
Component of the oligosaccharyltransferase (OST) complex, which appears to exist in two assemblies comprising OST1, OST2, OST4, OST5, STT3, SWP1, WPB1, and either OST3 or OST6 (PubMed:15831493, PubMed:15886282, PubMed:16096345, PubMed:16297388, PubMed:29301962, PubMed:8175708, PubMed:9405463). OST assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains OST1 and OST5,…
Endoplasmic reticulum membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8AGE | EM | 2.8 Å | E=1-476 |
| 8AGB | EM | 3.0 Å | E=1-476 |
| 8AGC | EM | 3.1 Å | E=1-476 |
| 6EZN | EM | 3.3 Å | A=1-476 |
| 7OCI | EM | 3.46 Å | A=1-476 |
| 6C26 | EM | 3.5 Å | 1=1-476 |
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