Glycyl-poneratoxin is a 26-residue protein from Paraponera clavata. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P41736.
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The mean pLDDT of this model is 77.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 89% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Toxin that causes pain in vertebrates by targeting tetrodotoxin (TTX)-sensitive sodium channels in peripheral sensory neurons (PubMed:37221205). Also blocks synaptic transmission and stimulates smooth muscle contraction (PubMed:12097919, PubMed:1685424, PubMed:1685425). Converts the normally rapidly activating and inactivating sodium channel current into one that does not inactivate (PubMed:27266841, PubMed:37221205). Is active on both Nav1.6/SCN8A and Nav1.7/SCN9A sodium channels, with a much potent activity on Nav1.6/SCN8A (EC(50)=97 nM on human channels) than on Nav1.7/SCN9A (EC(50)=2.3 uM on human and EC(50)=1.8 uM on mouse channels) (PubMed:27266841, PubMed:37221205). On these…
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1G92 | NMR | A=1-25 |
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