Phosphatidylinositol 4-kinase alpha (PI4KA) is a 2102-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P42356.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 79.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 34% |
| 70 to 90 | Confident: backbone generally right | 48% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate
Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and HYCC (HYCC1 or HYCC2) (PubMed:23229899, PubMed:24417819, PubMed:26571211, PubMed:34415310). Interacts with TMEM150A; regulating recruitment to the plasma membrane (PubMed:25608530). Interacts with TTC7A (PubMed:34415310)
Cytoplasm, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9B9G | EM | 3.5 Å | A/B=1-2102 |
| 9OT6 | EM | 3.54 Å | A/B=1-2102 |
| 6BQ1 | EM | 3.6 Å | A/E=932-2102 |
| 9BAX | EM | 3.65 Å | A/B=1-2102 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.