Protein AF-9 (MLLT3) is a 568-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P42568.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 61.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 31% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 56% |
What pLDDT means and how to read it
Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619, PubMed:30374167, PubMed:30385749). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds…
Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3) (PubMed:20159561, PubMed:20471948, PubMed:22195968, PubMed:23260655, PubMed:25417107, PubMed:30134174). Interacts with BCOR (PubMed:10898795). Interacts with CBX8 (PubMed:11313972). Interacts with ALKBH4 (PubMed:23145062). Interacts…
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8PJ7 | X-ray | 1.26 Å | A=1-142 |
| 7VKG | X-ray | 1.83 Å | A=1-138 |
| 5YYF | X-ray | 1.9 Å | A/C=1-138 |
| 6MIL | X-ray | 1.93 Å | A/C=1-138 |
| 7EIC | X-ray | 1.95 Å | A/B=1-138 |
| 7EID | X-ray | 2.0 Å | A/B=1-138 |
| 8TLX | X-ray | 2.1 Å | A=500-568 |
| 9ARR | X-ray | 2.1 Å | A/B=1-138 |
| 8TLW | X-ray | 2.11 Å | A=500-568 |
| 6LS6 | X-ray | 2.2 Å | A/B=1-138 |
| 7VKH | X-ray | 2.25 Å | A/B=1-138 |
| 4TMP | X-ray | 2.3 Å | A/C=1-138 |
| 9ARO | X-ray | 2.3 Å | A/B/C/D=1-138 |
| 6MIM | X-ray | 2.52 Å | A/C=1-138 |
| 8TLV | X-ray | 2.66 Å | A=500-568 |
| 5HJB | X-ray | 2.7 Å | A=1-138 |
| 9IM4 | X-ray | 2.79 Å | A/B=1-138 |
| 5HJD | X-ray | 2.81 Å | A/C/E/G/K/N/Q/T=1-138 |
| 8Z73 | X-ray | 2.91 Å | A/B/D/F=1-138 |
| 6L5Z | X-ray | 3.05 Å | A=1-138 |
Showing 20 of 26 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.