Putrescine aminotransferase (patA) is a 459-residue protein from Escherichia coli (strain K12). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P42588.
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The mean pLDDT of this model is 95.8 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 92% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline (PubMed:12617754, PubMed:3510672). This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4-aminobutanal, which allows E.coli to grow on putrescine as the sole nitrogen source (PubMed:22636776, PubMed:3510672). Also functions as a cadaverine transaminase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate (PubMed:12617754, PubMed:30498244). Is also able to…
Homodimer
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8CPL | X-ray | 1.6 Å | A/B/C/D=7-457 |
| 4UOX | X-ray | 2.08 Å | A/B/C/D=1-459 |
| 8R2P | X-ray | 2.22 Å | A/B/C/D=7-457 |
| 4UOY | X-ray | 2.3 Å | A/B/C/D=1-459 |
| 5H7D | X-ray | 2.57 Å | A/B/C/D/I/J/M/N=7-453 |
| 5X3F | X-ray | 3.38 Å | A=7-453 |
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