Tropomyosin alpha-1 chain (TPM1) is a 284-residue protein from Sus scrofa. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P42639.
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The mean pLDDT of this model is 91.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 75% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments
Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain. Interacts with HRG (via the HRR domain); the interaction contributes to the antiangiogenic properties of the histidine/proline-rich region (HRR) of HRG. Interacts (via N-terminus) with LMOD2 (via N-terminus) and TMOD1 (via N-terminus)
Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8DD0 | EM | 3.5 Å | G/H/I/J/L/M/N/O=1-284 |
| 8UWW | EM | 5.1 Å | F/G=1-284 |
| 8V0K | EM | 5.2 Å | F/G=1-284 |
| 8UYD | EM | 5.3 Å | F/G=1-284 |
| 8UZY | EM | 5.3 Å | F/G=1-284 |
| 8UZX | EM | 5.4 Å | F/G=1-284 |
| 8UWY | EM | 5.5 Å | F/G=1-284 |
| 8V01 | EM | 5.5 Å | F/G=1-284 |
| 8V0I | EM | 5.8 Å | F/G=1-284 |
| 8UZ5 | EM | 5.9 Å | F/G=1-284 |
| 8UWX | EM | 6.0 Å | F/G=1-284 |
| 1C1G | X-ray | 7.0 Å | A/B/C/D=1-284 |
| 8V0Y | EM | 7.0 Å | F/G=1-284 |
| 8UZ6 | EM | 7.1 Å | F/G=1-284 |
| 7KO5 | EM | 7.8 Å | P/Q/R/S/W/X/Y/Z=1-284 |
| 7KOR | EM | 7.8 Å | P/Q/R/S/W/X/Y/Z=1-284 |
| 7KO4 | EM | 8.0 Å | P/Q/R/S/W/X/Y/Z=1-284 |
| 7KON | EM | 8.1 Å | P/Q/R/S/W/X/Y/Z=1-284 |
| 7KO7 | EM | 8.3 Å | P/Q/R/S/W/X/Y/Z=1-284 |
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