CBK1 kinase activator protein MOB2 (MOB2) is a 287-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P43563.
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The mean pLDDT of this model is 66.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 7% |
| 70 to 90 | Confident: backbone generally right | 45% |
| 50 to 70 | Low: treat with caution | 16% |
| Below 50 | Very low: often disordered regions | 32% |
What pLDDT means and how to read it
Functions as an activator subunit for the CBK1 protein kinase. Part of the regulation of ACE2 activity and cellular morphogenesis (RAM) signaling network. Required for coordinating polarized cell growth during interphase with the onset of mitosis. Required for mother/daughter cell separation after cytokinesis. Also has a role in the prevention of nuclear export of ACE2 from the daughter cell nucleus after mitotic exit. It coordinates ACE2-dependent transcription with mitotic exit network activation
Interacts with protein kinase CBK1 to form the RAM CBK1-MOB2 kinase complex
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5NCM | X-ray | 2.8 Å | A=44-287 |
| 5NCL | X-ray | 3.15 Å | B=46-287 |
| 4LQS | X-ray | 3.3 Å | B=46-287 |
| 4LQQ | X-ray | 3.6 Å | B/E=46-287 |
| 4LQP | X-ray | 4.5 Å | B=46-287 |
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