Non-selective voltage-gated ion channel VDAC2 (VDAC2) is a 294-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P45880.
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The mean pLDDT of this model is 92.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 82% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:8420959). The channel adopts an open conformation at zero mV and a closed conformation at both positive and negative potentials (PubMed:8420959). There are two populations of channels; the main that functions in a lower open-state conductance with lower ion selectivity, that switch, in a voltage-dependent manner, from the open to a low-conducting 'closed' state and the other that has a normal ion selectivity in the typical high conductance, 'open' state (PubMed:8420959). Binds various lipids, including the sphingolipid ceramide, the…
Monomer, homodimer and higher order oligomers; formation of higher order structures is necessary for scramblase activity (PubMed:38065946). Interacts with ARMC12 in a TBC1D21-dependent manner (By similarity). Interacts with KLC3 (By similarity). Interacts with SPATA33 (By similarity). Interacts with PPP3CC in a SPATA33-dependent manner (By similarity). As a homodimer, interacts with the TOM…
Mitochondrion outer membrane, Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9EII | EM | 2.75 Å | F=1-294 |
| 9EIH | EM | 3.1 Å | E/F=1-294 |
| 9EIJ | EM | 3.3 Å | E/F=1-294 |
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