Chromobox protein homolog 5 (CBX5) is a 191-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P45973.
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The mean pLDDT of this model is 75.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 40% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 20% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression (PubMed:40440427). In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) (PubMed:19783980). Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me) (PubMed:16127177). Excluded from chromatin when histone H1.4 is Simultaneously methylated at Lys-26 (H1.4K26me) and phosphorylated at Ser-27 (H1.4S27Ph) (PubMed:16127177). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR) (PubMed:19783980). Involved in the formation…
Homodimer (PubMed:20819937). Interacts with histone H3 methylated at 'Lys-9' (PubMed:11242053, PubMed:21047797). Interacts (via Chromo 2; shadow subtype domain) with the MIS12 complex subunit NSL1; the interaction is direct, involves dimeric CBX5, and occurs during interphase (PubMed:15502821, PubMed:20231385, PubMed:20819937). Interacts with POGZ; POGZ and PXVXL motif-containing proteins such…
Nucleus, Chromosome, Chromosome, centromere
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3FDT | X-ray | 2.0 Å | A=18-75 |
| 9CEA | X-ray | 2.15 Å | A/B/C/D=113-175 |
| 9CDW | X-ray | 2.4 Å | A/B/C/D=111-174 |
| 3I3C | X-ray | 2.48 Å | A/B/C/D=110-173 |
| 9CMT | X-ray | 3.17 Å | A/B/D/E=112-176 |
| 8UXQ | EM | 6.3 Å | A/C=2-191 |
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