Ran GTPase-activating protein 1 (RANGAP1) is a 587-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P46060.
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The mean pLDDT of this model is 87.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 74% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050)
Homodimer (PubMed:8146159). Interacts with RAN (PubMed:16428860, PubMed:7891706, PubMed:8896452). Forms a complex with RANBP2/NUP358, NXF1 and NXT1 (PubMed:14729961). Forms a tight complex in association with RANBP2/NUP358 and UBE2I/UBC9, the ubiquitin-conjugating enzyme E2 (PubMed:15037602, PubMed:15931224, PubMed:22194619, PubMed:27160050). Interacts with UBE2I; the interaction conjugates…
Cytoplasm, Nucleus, nucleoplasm, Nucleus envelope, Chromosome, centromere, kinetochore, Cytoplasm, cytoskeleton, spindle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2GRR | X-ray | 1.3 Å | B=419-587 |
| 2GRO | X-ray | 1.7 Å | B=419-587 |
| 2GRQ | X-ray | 1.7 Å | B=419-587 |
| 2GRN | X-ray | 1.8 Å | B=419-587 |
| 2GRP | X-ray | 2.05 Å | B=419-587 |
| 3UIP | X-ray | 2.29 Å | C=419-587 |
| 5D2M | X-ray | 2.4 Å | C/F=418-587 |
| 3UIN | X-ray | 2.6 Å | C=419-587 |
| 3UIO | X-ray | 2.6 Å | C=419-587 |
| 2IY0 | X-ray | 2.77 Å | C=432-587 |
| 2IO2 | X-ray | 2.9 Å | C=418-587 |
| 9B62 | EM | 2.9 Å | G=1-587 |
| 1Z5S | X-ray | 3.01 Å | C=418-587 |
| 2IO3 | X-ray | 3.2 Å | C=418-587 |
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