Synaptotagmin-2 (Syt2) is a 422-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P46097.
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The mean pLDDT of this model is 80.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 55% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 19% |
What pLDDT means and how to read it
Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (PubMed:7961887). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (PubMed:7961887). Plays a role in dendrite formation by melanocytes (By similarity)
Homotetramer (Probable). Heterodimer; heterodimerizes with SYT1 in presence of calcium (By similarity). Interacts with SCAMP5 (By similarity). Interacts with STON2 (By similarity). Interacts with PRRT2 (PubMed:27052163)
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
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