Nuclear mRNA export protein SAC3 (SAC3) is a 1301-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P46674.
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The mean pLDDT of this model is 69.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 31% |
| 70 to 90 | Confident: backbone generally right | 30% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 31% |
What pLDDT means and how to read it
Component of the SAC3-THP1 complex, which functions in transcription-coupled mRNA export from the nucleus to the cytoplasm. SAC3-THP1 functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), by association with components of the nuclear mRNA export machinery (MEX67-MTR2 and SUB2) in the nucleoplasm and the nucleoporin NUP1 at the nuclear basket
Heterodimer with THP1. The SAC3-THP1 complex interacts with CDC31 and SUS1, and with the mRNA export factor MEX67-MTR2, the TREX complex component SUB2, and the nucleoporin NUP1. SAC3 directly interacts with MEX67, NUP1 and SUB2
Nucleus envelope
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8U8C | X-ray | 2.4 Å | A=60-551 |
| 3FWB | X-ray | 2.5 Å | B=752-805 |
| 4MBE | X-ray | 2.61 Å | B/E=753-805 |
| 3FWC | X-ray | 2.7 Å | B/F/J/N=723-805 |
| 3T5V | X-ray | 2.9 Å | A/D=250-563 |
| 4C31 | X-ray | 3.0 Å | A/D=757-787 |
| 8U8D | EM | 3.04 Å | A=60-551 |
| 4TRQ | X-ray | 3.1 Å | A/D=253-551 |
| 8U8E | EM | 3.33 Å | A=60-551 |
| 5L3T | X-ray | 4.93 Å | A=1-1301 |
| 5G5P | EM | 5.3 Å | A=1-805 |
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