Melatonin receptor type 1A (MTNR1A) is a 350-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P48039.
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The mean pLDDT of this model is 85.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 68% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Possibly involved in sleep induction, by melatonin activation of the potassium channel KCNMA1/BK and the dissociation of G-beta and G-gamma subunits, thereby decreasing synaptic transmission (By similarity)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6ME2 | X-ray | 2.8 Å | A=12-325 |
| 6ME3 | X-ray | 2.9 Å | A=12-325 |
| 7VGY | EM | 3.1 Å | A=1-350 |
| 6ME4 | X-ray | 3.2 Å | A=12-325 |
| 6ME5 | X-ray | 3.2 Å | A=12-325 |
| 6PS8 | X-ray | 3.3 Å | A=12-218, A=228-325 |
| 7DB6 | EM | 3.3 Å | D=1-340 |
| 7VGZ | EM | 3.3 Å | B=1-350 |
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