Beta-diguetoxin-Dc1a is a 94-residue protein from Diguetia canities. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P49126.
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The mean pLDDT of this model is 78.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 33% |
| 70 to 90 | Confident: backbone generally right | 37% |
| 50 to 70 | Low: treat with caution | 28% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Insecticidal toxin (PubMed:8541888, PubMed:8896202). This toxin promotes opening of insect Nav channels. The toxin binds to the S1-S2 and S3-S4 loops in the domain II voltage-sensor of insect Nav channels (i.e., receptor site 4). The American cockroach P.americana is largely resistant to the effects of this toxin due to an unusual sequence within the domain II S1-S2 loop. In vivo, paralyzes lepidopteran and dipteran larvae. Paralyzed insects ultimately die from secondary effects of starvation and dehydration (PubMed:25014760)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6A95 | EM | 2.6 Å | B=39-94 |
| 6A90 | EM | 2.8 Å | B=39-94 |
| 8F0S | EM | 3.1 Å | B=39-94 |
| 6A91 | EM | 3.2 Å | B=39-94 |
| 2MI5 | NMR | A=39-94 |
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