Vascular endothelial growth factor B (VEGFB) is a 207-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P49765.
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The mean pLDDT of this model is 73.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 35% |
| 70 to 90 | Confident: backbone generally right | 16% |
| 50 to 70 | Low: treat with caution | 32% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis
Homodimer; disulfide-linked. Can also form heterodimer with VEGF
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6TKK | X-ray | 1.06 Å | B=144-148 |
| 2C7W | X-ray | 2.48 Å | A/B=31-129 |
| 2XAC | X-ray | 2.71 Å | A/B=31-129 |
| 2VWE | X-ray | 3.4 Å | A/B=22-149 |
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