Double-strand break repair protein MRE11 (MRE11) is a 708-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P49959.
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The mean pLDDT of this model is 75.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 48% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 28% |
What pLDDT means and how to read it
Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:11741547, PubMed:14657032, PubMed:22078559, PubMed:23080121, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:28867292, PubMed:29670289, PubMed:30464262, PubMed:30612738, PubMed:31353207, PubMed:37696958, PubMed:38128537, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:24316220, PubMed:28867292, PubMed:31353207,…
Component of the MRN complex composed of two heterodimers RAD50 and MRE11 associated with a single NBN (PubMed:10839544, PubMed:26215093, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complexes dimerize on DNA to form joined MRN-MRN oligomers required for DNA double-strand break repair (PubMed:36577401). As part of the MRN complex, interacts with MCM9; the interaction…
Nucleus, Chromosome, Chromosome, telomere
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8K00 | X-ray | 1.4 Å | B=538-563 |
| 9Q9K | EM | 2.59 Å | D/E=1-708 |
| 9Q9J | EM | 2.71 Å | D/E=1-708 |
| 9Q9I | EM | 2.79 Å | D/E=1-708 |
| 9Q9M | EM | 2.81 Å | D/E=1-708 |
| 3T1I | X-ray | 3.0 Å | A/B/C/D=1-411 |
| 9Q9H | EM | 3.11 Å | D/E=1-708 |
| 9ULO | EM | 3.91 Å | A/B=1-708 |
| 7ZQY | EM | 4.13 Å | A/B=1-708 |
| 8BAH | EM | 4.13 Å | A/B=1-708 |
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