Type-2 angiotensin II receptor (AGTR2) is a 363-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P50052.
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The mean pLDDT of this model is 82.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 58% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 15% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Receptor for angiotensin II, a vasoconstricting peptide (PubMed:28379944, PubMed:29967536, PubMed:31899086, PubMed:8185599). Primarily signals via a non-canonical G protein- and beta-arrestin independent pathways (PubMed:28379944). Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (PubMed:15123706)
Interacts with MTUS1
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5UNF | X-ray | 2.8 Å | A/B=35-335 |
| 5UNG | X-ray | 2.8 Å | B=35-335 |
| 5UNH | X-ray | 2.9 Å | A/B=35-335 |
| 7JNI | X-ray | 3.0 Å | A/B=35-335 |
| 5XJM | X-ray | 3.2 Å | A=35-242, A=246-346 |
| 6JOD | X-ray | 3.2 Å | A=35-346 |
| 7C6A | X-ray | 3.4 Å | A=35-242, A=246-346 |
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