DNA-binding transcriptional repressor Mlc (mlc) is a 406-residue protein from Escherichia coli (strain K12). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P50456.
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The mean pLDDT of this model is 93.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 86% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Global regulator of carbohydrate metabolism (PubMed:10464268, PubMed:11361067, PubMed:11934616, PubMed:9484892, PubMed:9484893, PubMed:9781886). Represses the expression of several genes involved in sugar transport and utilization, in particular phosphoenolpyruvate-carbohydrate phosphotransferase system (PTS) genes (PubMed:10464268, PubMed:9484892, PubMed:9484893, PubMed:9781886). Represses expression of ptsG (EIICB(Glc)), which encodes the PTS system glucose-specific EIICB component (PubMed:9781886). Also represses the expression of the manXYZ operon, encoding the mannose-specific PTS system, expression of malT, encoding the transcriptional activator of the maltose regulon, and expression…
Homodimer (PubMed:15929984). Homotetramer (PubMed:12529317, PubMed:15929984, PubMed:16510988, PubMed:18319344). There is probably an equilibrium between the dimeric and the tetrameric form (PubMed:15929984). Interacts with dephosphorylated PtsG (PubMed:11032803, PubMed:11157755, PubMed:12529317, PubMed:18319344). Mlc and PtsG EIIB domain form a complex with the 1:1 stoichiometry…
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
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