Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (PDE6C) is a 858-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P51160.
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The mean pLDDT of this model is 88.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 63% |
| 70 to 90 | Confident: backbone generally right | 29% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Catalytic alpha subunit of the cone-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP as part of the phototransduction cascade. The PDE6 holoenzyme consists of two catalytic alpha subunits (PDE6C) and two inhibitory gamma subunits (PDE6H) (PubMed:21127010, PubMed:28583373, PubMed:39739818). Light-activated GNAT2 relieves gamma subunit-mediated inhibition, allowing the catalytic subunits to hydrolyze cGMP and mediate visual signal transduction and amplification. The resulting decrease in cytosolic cGMP levels triggers the closure of cGMP-gated cation channels at the plasma membrane, leading to hyperpolarization of cone photoreceptors (By similarity). The…
Tetramer composed of homodimeric catalytic chains (alpha' subunit/PDE6C) each one accociated with one inhibitory chain (gamma subunit/PDE6H)
Photoreceptor outer segment membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5E8F | X-ray | 2.1 Å | D/E=851-855 |
| 3JWQ | X-ray | 2.87 Å | A/B/C/D=746-785 |
| 3JWR | X-ray | 2.99 Å | A/B=746-785 |
| 9CXG | EM | 3.0 Å | A/B=2-830 |
| 9CXI | EM | 3.0 Å | A/B=2-830 |
| 9CXH | EM | 3.1 Å | A/B=2-830 |
| 9CXJ | EM | 3.1 Å | A/B=2-830 |
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