Nuclear receptor ROR-gamma (RORC) is a 518-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P51449.
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The mean pLDDT of this model is 74.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 55% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 28% |
What pLDDT means and how to read it
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism (PubMed:19381306, PubMed:19965867, PubMed:20203100, PubMed:22789990, PubMed:26160376). Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively (PubMed:19965867, PubMed:22789990). Recruits…
Interacts (via AF-2 motif) with the coactivator NCOA2 (via LXXLL motif) (PubMed:20211758). Interacts with the corepressor NCOR1 (By similarity). Interacts with CRY1 (PubMed:22170608). Interacts (via AF-2 motif) with the coactivators NCOA1 and PPARGC1A (via LXXLL motif) (By similarity). Interacts (via AF-2 motif) with PROX1 (By similarity). Interacts with FOXP3 (PubMed:18368049). Interacts with…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7NPC | X-ray | 1.47 Å | A=268-507 |
| 6T4X | X-ray | 1.48 Å | A=265-507 |
| 5APH | X-ray | 1.54 Å | A=265-507 |
| 6R7K | X-ray | 1.54 Å | A=265-507 |
| 7NP5 | X-ray | 1.55 Å | A=265-507 |
| 6SAL | X-ray | 1.61 Å | A=265-507 |
| 6W9I | X-ray | 1.61 Å | A=265-508 |
| 7OFK | X-ray | 1.61 Å | A=265-507 |
| 6T4T | X-ray | 1.62 Å | A=267-507 |
| 7KXD | X-ray | 1.62 Å | A=265-508 |
| 5NTW | X-ray | 1.64 Å | A/B/C/D=263-518 |
| 9N9L | X-ray | 1.64 Å | A/B=265-507 |
| 6G07 | X-ray | 1.66 Å | A/B/C/D=263-518 |
| 4WLB | X-ray | 1.7 Å | A/B=262-507 |
| 5NTP | X-ray | 1.7 Å | A=263-499 |
| 6T4W | X-ray | 1.71 Å | A=268-507 |
| 5G42 | X-ray | 1.72 Å | A=265-507 |
| 3L0L | X-ray | 1.74 Å | A/B=260-507 |
| 5G46 | X-ray | 1.76 Å | A=265-507 |
| 6TLQ | X-ray | 1.76 Å | A=265-507 |
Showing 20 of 160 experimental structures (best resolution first).
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