Large ribosomal subunit protein bL12m (MRPL12) is a 198-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P52815.
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The mean pLDDT of this model is 66.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 14% |
| 70 to 90 | Confident: backbone generally right | 38% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 35% |
What pLDDT means and how to read it
As a component of the mitochondrial large ribosomal subunit, plays a role in mitochondrial translation (PubMed:23603806). When present in mitochondria as a free protein not associated with the ribosome, associates with mitochondrial RNA polymerase POLRMT to activate transcription (PubMed:22003127). Required for POLRMT stability (PubMed:26586915)
Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:8626705). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which…
Mitochondrion matrix
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7QI4 | EM | 2.21 Å | t/u/v/w/x/y=1-198 |
| 7O9M | EM | 2.5 Å | t1/t2/t3/t4/t5/t6=1-198 |
| 7PO4 | EM | 2.56 Å | t/u/v/w/x/y=1-198 |
| 6ZM6 | EM | 2.59 Å | t1/t2/t3/t4/t5/t6=1-198 |
| 9CN3 | EM | 2.62 Å | TA/TB/TC=1-198 |
| 7QI5 | EM | 2.63 Å | t/u/v/w/x/y=1-198 |
| 8ANY | EM | 2.85 Å | t/u/v/w/x/y=1-198 |
| 6ZM5 | EM | 2.89 Å | t1/t2/t3/t4/t5/t6=1-198 |
| 8OIT | EM | 2.9 Å | B1/B2/B3/B4/B5/B6=1-198 |
| 6VMI | EM | 2.96 Å | TA/TB/TC=1-198 |
| 6VLZ | EM | 2.97 Å | TA/TB/TC=1-198 |
| 7QI6 | EM | 2.98 Å | t/u/v/w/x/y=1-198 |
| 9UWH | EM | 3.0 Å | t=1-198 |
| 7PO2 | EM | 3.09 Å | t=1-198 |
| 7O9K | EM | 3.1 Å | FF/t1/t2/t3/t4/t5/t6=1-198 |
| 8OIR | EM | 3.1 Å | B1/B2/B3/B4/B5/B6=1-198 |
| 7L20 | EM | 3.15 Å | TA/TB/TC=1-198 |
| 7L08 | EM | 3.49 Å | TA/TB=1-198 |
| 6ZSC | EM | 3.5 Å | t1/t2/t3/t4/t5/t6=1-198 |
| 6ZSD | EM | 3.7 Å | t1/t2/t3/t4/t5/t6=1-198 |
Showing 20 of 27 experimental structures (best resolution first).
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