Importin subunit beta-5 (KAP114) is a 1004-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P53067.
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The mean pLDDT of this model is 88.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 68% |
| 70 to 90 | Confident: backbone generally right | 25% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Serves a receptor for nuclear localization signals (PubMed:10535958, PubMed:11309407). Mediates the nuclear import of TATA-binding protein (TBP) (PubMed:10535958). Also acts as a nuclear import receptor for histone H2A-H2B dimers; together with co-chaperone NAP1 and Ran-GTP GSP1 it then facilitates the specific and accurate deposition of H2A-H2B into nucleosomes (PubMed:11309407)
Interacts (via C-terminus) with NAP1; the interaction is direct and for the nuclear import of histone H2A-H2B dimers and their assembly into nucleosomes (PubMed:18086883, PubMed:39601790). Interacts (via C-terminus) with histones H2A and H2B; the interaction is direct and for the nuclear import of histone H2A-H2B dimers and their assembly into nucleosomes (PubMed:39601790). Interacts (via…
Cytoplasm, Nucleus envelope
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6AHO | X-ray | 2.5 Å | A=1-1004 |
| 9B3I | EM | 2.88 Å | A=1-1004 |
| 9B31 | EM | 3.2 Å | A=1-1004 |
| 8F0X | EM | 3.21 Å | A=1-1004 |
| 8F1E | EM | 3.28 Å | A=1-1004 |
| 8F19 | EM | 3.49 Å | A=1-1004 |
| 9B3F | EM | 3.54 Å | A=1-1004 |
| 8H5B | EM | 4.03 Å | A=1-1004 |
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