Chromatin-remodeling ATPase INO80 (INO80) is a 1489-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P53115.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 64.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 11% |
| 70 to 90 | Confident: backbone generally right | 37% |
| 50 to 70 | Low: treat with caution | 21% |
| Below 50 | Very low: often disordered regions | 31% |
What pLDDT means and how to read it
ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair (PubMed:10952318, PubMed:12887900). Its ability to induce transcription of some phosphate-responsive genes is modulated by inositol polyphosphates (PubMed:10361278, PubMed:10952318). The INO80 complex is involved in DNA repair by associating with 'Ser-129' phosphorylated H2A histones as a response to DNA damage (PubMed:15607974, PubMed:15607975)
Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9C9Z | EM | 2.55 Å | Q=1-1489 |
| 8ETW | EM | 2.64 Å | Q=948-1432 |
| 8ETU | EM | 2.8 Å | Q=948-1432 |
| 9CAT | EM | 2.9 Å | Q=1-1489 |
| 9C9G | EM | 2.91 Å | Q=1-1489 |
| 9CCD | EM | 3.01 Å | Q=1-1489 |
| 8ETS | EM | 3.04 Å | Q=948-1432 |
| 9C9S | EM | 3.09 Å | Q=1-1489 |
| 9C9T | EM | 3.16 Å | Q=1-1489 |
| 8A5O | EM | 3.2 Å | G=1-598 |
| 9OB1 | EM | 3.2 Å | Q=1-1489 |
| 8A5A | EM | 3.3 Å | G=1-598 |
| 9CAN | EM | 3.3 Å | Q=1-1489 |
| 8EUF | EM | 3.41 Å | Q=1-1489 |
| 8EU9 | EM | 3.48 Å | Q=948-1440 |
| 5NBN | X-ray | 4.0 Å | G/H=462-598 |
| 9CB7 | EM | 4.04 Å | Q=1-1489 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.