Vacuolar protein sorting-associated protein 75 (VPS75) is a 264-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P53853.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 88.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 77% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Histone chaperone which acts as a cofactor stimulating histone H3 acetylation by RTT109 (PubMed:17320445, PubMed:19172748, PubMed:21256037, PubMed:29300933, PubMed:31387991). Preferentially stimulates histone H3 'Lys-9' acetylation by RTT109 (PubMed:21256037, PubMed:29300933, PubMed:31387991). May also stimulate histone H3 'Lys-56' acetylation by RTT109 (PubMed:17320445). Assembles nucleosomes (in vitro) (PubMed:19172748)
Homodimer (PubMed:19172748, PubMed:21256037, PubMed:21454705, PubMed:31387991). Homotetramer (PubMed:27036862). Forms a complex with RTT109; consisting of a VPS75 dimer contacted by two RTT109 subunits (PubMed:17320445, PubMed:18719104, PubMed:20560668, PubMed:21256037, PubMed:21454705, PubMed:31387991). Interacts with RTT109; the interaction is direct (PubMed:17272723, PubMed:17320445,…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2ZD7 | X-ray | 1.85 Å | A/B=1-264 |
| 3C9D | X-ray | 2.0 Å | A/B=1-259 |
| 3DM7 | X-ray | 2.0 Å | A/B=1-232 |
| 3C9B | X-ray | 2.42 Å | A/B=1-259 |
| 3Q66 | X-ray | 2.7 Å | A/B=1-264 |
| 3Q68 | X-ray | 2.7 Å | A/B=1-264 |
| 3Q33 | X-ray | 2.8 Å | B=1-232 |
| 3Q35 | X-ray | 3.3 Å | B=1-232 |
| 5AGC | X-ray | 4.0 Å | A/B/C/D=1-264 |
| 6O22 | Other | A/B=1-264 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.