Serine/threonine-protein kinase MPS1 (MPS1) is a 764-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P54199.
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The mean pLDDT of this model is 61.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 23% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 46% |
What pLDDT means and how to read it
Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (By similarity). Phosphorylates SPC105 on MELT motifs; phosphorylation is required for recruitment of the BUB1-BUB3 complex to kinetochores (PubMed:22521787). Phosphorylates CNN1, which contributes to the enrichment of CNN1 on anaphase kinetochores (PubMed:22561345). Implicated in spindle pole body (SPD) duplication. Phosphorylates the SPC29 and SPC110 spindle pole body components (PubMed:11278681, PubMed:19269975)
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8V10 | X-ray | 3.02 Å | B=136-171 |
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