Growth arrest-specific protein 1 (GAS1) is a 345-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P54826.
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The mean pLDDT of this model is 69.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 30% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 21% |
| Below 50 | Very low: often disordered regions | 27% |
What pLDDT means and how to read it
Coreceptor required for sonic hedgehog (SHH) handoff to its receptor: binds to the dually lipid-modified Sonic hedgehog protein N-product (ShhN) downstream of the CDON-BOC heterodimer and directly transfers ShhN to its patched receptor (PTCH1 or PTCH2), followed by activation of the smoothened signaling pathway (PubMed:35231446). Specifically recognizes and binds palmitate and cholesterol moieties in dually lipid-modified ShhN (PubMed:35231446). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity). Acts as a growth arrest protein involved in growth suppression by blocking entry to S phase (PubMed:8127893)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7RHQ | EM | 3.53 Å | G=40-317 |
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