Urocortin (UCN) is a 124-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P55089.
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The mean pLDDT of this model is 68.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 24% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 23% |
| Below 50 | Very low: often disordered regions | 29% |
What pLDDT means and how to read it
Hormone that plays a central role in whole body adaptation to stress (PubMed:20966082, PubMed:24290358, PubMed:32004470, PubMed:36335102, PubMed:8612563). Released by the hypothalamus primarily in response to physical or psychological stress and acts by binding to CRH receptors CRHR1 and CRHR2 (PubMed:24290358, PubMed:26350463, PubMed:32004470, PubMed:36335102, PubMed:8612563). UCN-dependent signaling is a primary mediator of the neuroendocrine, autonomic (fight-or-flight) and behavioral responses to stress, acting as a key regulator of adaptation by activating the hypothalamus-pituitary-adrenal axis, leading to corticotropin hormone (ACTH) production (PubMed:8612563). Plays a role in the…
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3N96 | X-ray | 2.75 Å | E/F/G/H=107-122 |
| 6PB1 | EM | 2.8 Å | U=83-122 |
| 7TS0 | EM | 2.8 Å | U=83-122 |
| 6PB0 | EM | 3.0 Å | U=83-122 |
| 7TRY | EM | 3.7 Å | U=83-122 |
| 2RMF | NMR | A=83-122 |
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