cAMP-regulated phosphoprotein 19 (ARPP19) is a 112-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P56211.
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The mean pLDDT of this model is 68.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 3% |
| 70 to 90 | Confident: backbone generally right | 46% |
| 50 to 70 | Low: treat with caution | 43% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) (PubMed:28167675, PubMed:38123684). Inhibition of PP2A is enhanced when ARPP19 is phosphorylated (PubMed:28167675, PubMed:38123684). When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (PubMed:21164014). May indirectly enhance GAP-43 expression (By similarity)
Interacts (when phosphorylated at Ser-62) with PPP2R2D (By similarity). Interacts with SNCA (PubMed:17893145). Interacts with PPP2R2A; the interaction is direct and this interaction inhibits PP2A activity (PubMed:38123684). Interacts with PPP2R1A (PubMed:28167675)
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8TTB | EM | 2.77 Å | D=1-112 |
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