C-terminal-binding protein 2 (CTBP2) is a 445-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P56545.
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The mean pLDDT of this model is 83.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 74% |
| 70 to 90 | Confident: backbone generally right | 0% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity)
Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with HIPK2 and ZNF217. Interacts with PRDM16; represses white adipose tissue (WAT)-specific genes expression (By similarity). Interacts with PNN, NRIP1 and WIZ. Interacts with MCRIP1 (PubMed:25728771)
Nucleus, Synapse
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9WRI | X-ray | 1.85 Å | A/B=31-364 |
| 8ATI | X-ray | 2.6 Å | A/B/C/D=31-364 |
| 2OME | X-ray | 2.8 Å | A/B/C/D/E/F/G/H=31-364 |
| 4LCJ | X-ray | 2.86 Å | A/B/C/D/E/F/G/H=31-362 |
| 6WKW | EM | 3.6 Å | A/B/C/D=33-362 |
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