Potassium voltage-gated channel subfamily KQT member 4 (KCNQ4) is a 695-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P56696.
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The mean pLDDT of this model is 65.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 24% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 39% |
What pLDDT means and how to read it
Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of sensory cells excitability in the cochlea (PubMed:10025409, PubMed:34767770). KCNQ4/Kv7.4 channel is composed of 4 pore-forming subunits assembled as tetramers (PubMed:34767770). Promotes the outflow of potassium ions in the repolarization phase of action potential which plays a role in regulating membrane potential of excitable cells (PubMed:10025409, PubMed:11245603, PubMed:34767770). The channel conducts a slowly activating and deactivating current (PubMed:10025409, PubMed:11245603). Current often shows some inward rectification at positive potentials (PubMed:10025409). Channel may be…
Homotetramer (PubMed:17329207). Interacts (via C-terminus) with calmodulin; forms a heterooctameric structure (with 4:4 KCNQ1:CALM stoichiometry); the interaction is calcium-independent, constitutive, participates in the proper assembly of a functional channel (PubMed:29429937, PubMed:34767770). The interaction with calcium-free CALM controls channel trafficking whereas interaction with…
Basal cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2OVC | X-ray | 2.07 Å | A=610-640 |
| 6N5W | X-ray | 2.15 Å | A=336-362, B=524-549 |
| 6B8N | X-ray | 2.2 Å | A/C/E/G=325-367, A/C/E/G=370-398 |
| 6B8P | X-ray | 2.2 Å | A/C/E/G=325-367, A/C/E/G=370-398 |
| 6B8L | X-ray | 2.3 Å | A/C/E/G=325-367, A/C/E/G=370-398 |
| 6B8M | X-ray | 2.3 Å | A/C/E/G=325-367, A/C/E/G=370-398 |
| 7BYL | EM | 2.5 Å | A/C/E/G=1-695 |
| 4GOW | X-ray | 2.6 Å | A=522-593 |
| 7VNP | EM | 2.79 Å | A/C/E/G=2-650 |
| 7VNR | EM | 2.8 Å | A/C/E/G=2-650 |
| 7VNQ | EM | 2.96 Å | A/C/E/G=2-650 |
| 7BYM | EM | 3.1 Å | A/C/E/G=1-695 |
| 7BYN | EM | 3.3 Å | A/C/E/G=1-695 |
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