ORF6 protein (6) is a 63-residue protein from Severe acute respiratory syndrome coronavirus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P59634.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 80.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 43% |
| 70 to 90 | Confident: backbone generally right | 25% |
| 50 to 70 | Low: treat with caution | 32% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Disrupts bidirectional nucleocytoplasmic transport by interacting with host RAE1-NUP98 complex (PubMed:33849972). Disrupts cell nuclear import complex formation also by tethering karyopherin alpha 2 and karyopherin beta 1 to the membrane (PubMed:17596301). Retention of import factors at the ER/Golgi membrane leads to a loss of transport into the nucleus (PubMed:17596301). Thereby prevents STAT1 nuclear translocation in response to interferon signaling, thus blocking the expression of interferon stimulated genes (ISGs) that display multiple antiviral activities (PubMed:17596301)
May interact with nsp8 (PubMed:17532020). Interacts with protein ORF9b (PubMed:22820404). Interacts with host RAE1 in NUP98-RAE1 complex (PubMed:35096974); the interaction disrupts the host nuclear import (PubMed:33849972). Interacts with host KPNA2 (PubMed:17596301)
Host endoplasmic reticulum membrane, Host Golgi apparatus membrane, Host cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
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