Interleukin-1 receptor accessory protein-like 1 (Il1rapl1) is a 695-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P59823.
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The mean pLDDT of this model is 76.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 42% |
| 70 to 90 | Confident: backbone generally right | 29% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK (By similarity). Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (PubMed:21940441, PubMed:25908590)
Homodimer (PubMed:25908590). Interacts (calcium-independent) with NCS1/FREQ (By similarity). Interacts (via the first immunoglobulin domain) with PTPRD (via the second immunoglobulin domain); this interaction is PTPRD-splicing-dependent and induces pre- and post-synaptic differentiation of neurons and is required for IL1RAPL1-mediated synapse formation (PubMed:21940441, PubMed:25908590)
Cell membrane, Cytoplasm, Cell projection, axon, Cell projection, dendrite
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5Y32 | X-ray | 2.7 Å | B=19-352 |
| 4YH6 | X-ray | 3.0 Å | A/B=19-352 |
| 4YH7 | X-ray | 4.4 Å | B=19-352 |
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