Large ribosomal subunit protein uL22 (rplV) is a 110-residue protein from Escherichia coli (strain K12). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P61175.
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The mean pLDDT of this model is 96.0 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 96% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 0% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. uL4, bL17, and bL20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome
Part of the 50S ribosomal subunit (PubMed:10094780, PubMed:11511371, PubMed:12809609, PubMed:16272117, PubMed:24844575, PubMed:25310980, PubMed:27906160, PubMed:27906161, PubMed:27934701, PubMed:34403461, PubMed:34504068, PubMed:7007072). In TnaC-stalled ribosomes forms part of the binding pocket for L-Trp with the leader peptide and uL4 (PubMed:34403461, PubMed:34504068)
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8B0X | EM | 1.55 Å | r=1-110 |
| 9Q87 | EM | 1.55 Å | r=1-110 |
| 8CGK | EM | 1.64 Å | r=1-110 |
| 8CGV | EM | 1.66 Å | r=1-110 |
| 8CEU | EM | 1.83 Å | r=1-110 |
| 8FTO | EM | 1.85 Å | r=1-110 |
| 8CAM | EM | 1.86 Å | r=1-110 |
| 9GHE | EM | 1.87 Å | r=1-110 |
| 8E30 | EM | 1.91 Å | P=1-110 |
| 9D89 | EM | 1.95 Å | r=1-110 |
| 8AYE | EM | 1.96 Å | r=1-110 |
| 7K00 | EM | 1.98 Å | r=1-110 |
| 8CGD | EM | 1.98 Å | r=1-110 |
| 8E3O | EM | 1.99 Å | P=1-110 |
| 8QOA | EM | 2.0 Å | r=1-110 |
| 8G6W | EM | 2.02 Å | r=1-110 |
| 8BIL | EM | 2.04 Å | P=1-110 |
| 8BIM | EM | 2.04 Å | P=1-110 |
| 8E49 | EM | 2.05 Å | P=1-110 |
| 8E43 | EM | 2.09 Å | P=1-110 |
Showing 20 of 600 experimental structures (best resolution first).
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