cAMP-dependent protein kinase inhibitor alpha (PKIA) is a 76-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P61925.
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The mean pLDDT of this model is 65.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 3% |
| 70 to 90 | Confident: backbone generally right | 36% |
| 50 to 70 | Low: treat with caution | 46% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5M6Y | X-ray | 1.37 Å | B=6-25 |
| 5LCQ | X-ray | 1.42 Å | B=6-25 |
| 5M6V | X-ray | 1.42 Å | B=6-25 |
| 5LCP | X-ray | 1.43 Å | B=6-25 |
| 5M0L | X-ray | 1.47 Å | B=6-25 |
| 5M71 | X-ray | 1.49 Å | B=6-25 |
| 5M0B | X-ray | 1.51 Å | B=6-25 |
| 5M75 | X-ray | 1.54 Å | B=6-25 |
| 4IAI | X-ray | 1.55 Å | S=6-25 |
| 4WB8 | X-ray | 1.55 Å | I=6-25 |
| 4Z84 | X-ray | 1.55 Å | I=6-25 |
| 5LCR | X-ray | 1.56 Å | B=6-25 |
| 3OVV | X-ray | 1.58 Å | B=6-25 |
| 5LCU | X-ray | 1.58 Å | B=6-25 |
| 1XH8 | X-ray | 1.6 Å | B=6-25 |
| 3POO | X-ray | 1.6 Å | B=6-25 |
| 4IAK | X-ray | 1.6 Å | S=6-25 |
| 5LCT | X-ray | 1.61 Å | B=6-25 |
| 4IB1 | X-ray | 1.63 Å | S=6-25 |
| 7V0G | X-ray | 1.63 Å | I=6-24 |
Showing 20 of 114 experimental structures (best resolution first).
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