E3 ubiquitin-protein ligase RBX1 (Rbx1) is a 108-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P62878.
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The mean pLDDT of this model is 78.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 28% |
| 70 to 90 | Confident: backbone generally right | 44% |
| 50 to 70 | Low: treat with caution | 19% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair (PubMed:22118460, PubMed:33590678, PubMed:35978186). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components…
Component of multiple Cul1-RING E3 ubiquitin-protein ligase complexes commonly known as SCF (SKP1-CUL1-F-box) complexes, consisting of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein (By similarity). Part of a SCF(SKP2) complex consisting of CUL1, RBX1, SKP1 and SKP2 (By similarity). Part of a SCF(FBXO3) complex consisting of CUL1, FBXO3, RBX1 and SKP1; this complex interacts…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7OPC | EM | 3.0 Å | f=1-108 |
| 7OPD | EM | 3.0 Å | f=1-108 |
| 4A0C | X-ray | 3.8 Å | D/F=12-108 |
| 4A0K | X-ray | 5.93 Å | B=12-108 |
| 4A0L | X-ray | 7.4 Å | F/I=12-108 |
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